Research Interests

1. Micro/Nano-Scale Optical Imaging (Microfluidics): (a) Micro-/Nano-fabrication, (b)Confocal Laser Scanning Microscopy (CLSM) to measure the velocity field in a microchannel channel, (c)Optical Serial Sectioning Microscopy (OSSM) to examine thermometry by detecting the free Brownian motion of nano-particles suspended in mediums at different temperatures, (d) Total Internal Reflection Fluorescence Microscopy (TIRFM) to examine the hindered Brownian motion of nano-particles very close to a solid surface.

2. Cytometric Analysis Using and Developing Opto-Electric Biosensors : Simultaneous dynamic optical and electrical measurement using DICM image technique and electrical cell-substrate impedance sensing by using an opto-electric Indium Tin Oxide (ITO) biosensor

3. Cell Proliferation and Cytotoxicity Studies Using Biochemical Sensors: (a)Analysis for apoptosis, cytotoxicity, necrosis, and proliferation, (b) Adhesion protein analysis using IRCM & impedance measurement: LOX, COX1, & COX2, (c) Flow cytometric analysis using FAC-Scan

4. Synthetic Biology: (a) Enzyme Reaction using pico-liter cell mimic chamber. (b) Molecular transports using post-array cell mimics

5. CFD (Computational Fluid Dynamics)

Selected Publications

• M. Sukhthankar, C. K. Choi,, A. English, J. Kim, S. Baek, A potential proliferative gene, NUDT6, is down-regulated by green tea catechins at the post-transcriptional level, the Journal of Nutritional Biochemistry, Accepted, 2008
• G Park, C. K. Choi, A. English, T. Sparer, Electrical impedance measurements predict cellular transformation, Cell Biology International, Accepted, 2008
• S. Lee, J. Bahn, C.K. Choi, N. Whitlock, A. English, S. Safe, S. Baek, ESE-1/EGR-1 Pathway Plays a Role in Tolfenamic Acid-induced Apoptosis in Colorectal Cancer Cells, Molecular Cancer Therapeutics, Vol. 7, 3739-3750,  2008
• B. Green, R. Steward, I. Kim, C. K. Choi, P. Liaw, K. Kihm, Y. Yokoyama, In situ observation of pitting corrosion of the Zr50Cu40Al10 bulk metallic glass, Intermetallics, accepted, 2008.
• C. K. Choi, C. H. Margraves, K. D. Kihm, and A.E. English, Dynamic Fingerprinting of Cellular Focal Contacts under Cytotoxic Conditions Using Quantitative Analysis of Natural Fringes, Journal of Biomedical Optics, Vol. 13, Issue 5, 054069, 2008 [selected for the November 1, 2008 issue of Virtual Journal of Biological Physics Research.]
• C.K. Choi, A. English, K. Kihm, and C Margraves, Dynamic Optical and Electrical Properties of Endothelial Cell Attachment on Indium Tin Oxide Bio-electrodes, Journal of Biomedical Optics Vol. 12, Issue 6, 064028, 2007
• C.K. Choi, C. H. Margraves, and K. D. Kihm, Examination of Near-wall hindered Brownian diffusion of nanoparticles: Experimental validation of theories by Brenner (1961) and Goldman et al. (1967), Physics of fluids,  Vol. 19, Issue 10, 103305, 2007
• C.K. Choi, K. Kihm, and A. English, Opto-electric indium-tin-oxide (ITO) biosensor for simultaneous cellular imaging and micro-impedance analyses, Optics Letters, Vol. 32, Issue 11, pp1405-1407, 2007 [selected for the June 15, 2007 issue of Virtual Journal of Biological Physics Research.]
• C.K. Choi, A. English, S. Jun, K. Kihm, and P. Rack, An Endothelial Cell Compatible Biosensor Fabricated Using Optically Thin Indium Tin Oxide Silicon Nitride Electrodes, Biosensors and Bioelectronics, Vol. 22, pp. 2585-2590, 2007
• C. H. Margraves,C. K. Choi, and K. D. Kihm, Examination of the effect of salinity on the minimum elevation of nano-particles using ratiometric total internal reflection fluorescence microscopy (R-TIRFM), Experiments in fluids, Vol. 41, pp. 173-183, 2006